Inheritance pattern of molar-incisor hypomineralization

The aim of this study was to investigate the segregation patterns molar incisor hypomineralization (MIH) in families, given evidence that its etiology is influenced by genetics. Clinically, MIH may be detected parents and/or siblings MIH-affected children. Our included children with at least one first permanent affected (proband) and their first-degree relatives (parents siblings). participants were examined clinically detect MIH, according European Academy Paediatric Dentistry criteria (2003). A total 101 nuclear families (391 individuals) studied. Proband diagnosis followed classification subject, his siblings, as affected, unaffected, or unknown. Segregation analysis performed using multivariate logistic regression model Statistical Analysis for Genetic Epidemiology package, models (general transmission, environmental, major gene, dominant, codominant recessive models). Akaike information criterion (AIC) used evaluate most parsimonious model. In all, 130 individuals, 165 unaffected 96 unknown individuals Severe found 50.7% cases. revealed following different models: environmental dominance (p = 0.05), gene 0.04), 0.15) 0.03). According AIC values, (AIC 308.36). results suggest could likely inheriting MIH. This result strengthens genetic factors, such multifactorial complex defect, influence